Adjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis.
Robert S WallisIssa SabiJulieth LalashowiAbhishek BakuliDaniel MapambaWillyhelmina OlomiElimina SiyameBeatrice NgaraguzaOmbeni ChimbeSalome CharalambousAndrea RachowOlena IvanovaLindsey ZurbaBahati MyombeRevocatus KunambiMichael HoelscherNyanda NtinginyaGavin ChurchyardPublished in: NEJM evidence (2024)
Despite increasing whole-blood glutathione levels, NAC did not affect eradication of MTB infection in adults with pulmonary tuberculosis that was moderate to far advanced. Secondary outcomes of lung function showed changes that merit further investigation. (Funded by TB SEQUEL grant 01KA1613 of the German Ministry for Education and Research, the Health Africa Project, and the German Center for Infection Research; ClinicalTrials.gov number, NCT03702738.).
Keyphrases
- pulmonary tuberculosis
- lung function
- mycobacterium tuberculosis
- cystic fibrosis
- chronic obstructive pulmonary disease
- air pollution
- healthcare
- quality improvement
- public health
- transcription factor
- mental health
- health information
- type diabetes
- helicobacter pylori infection
- adipose tissue
- metabolic syndrome
- skeletal muscle
- insulin resistance