Gold(I) and Silver(I) Complexes Containing Hybrid Sulfonamide/Thiourea Ligands as Potential Leishmanicidal Agents.
Alice P BorgesMalu M S ObataSilvia H LibardiRafael O TrevisanVictor M DeflonUlrich AbramFrancis B FerreiraLuiz Antônio S CostaAntonio Otavio T PatrocinioMarcos Vinícius da SilvaJúlio César BorgesPedro Ivo da Silva MaiaPublished in: Pharmaceutics (2024)
Leishmaniasis is a group of parasitic diseases with the potential to infect more than 1 billion people; however, its treatment is still old and inadequate. In order to contribute to changing this view, this work consisted of the development of complexes derived from M I metal ions with thioureas, aiming to obtain potential leishmanicidal agents. The thiourea ligands (HL R ) were obtained by reactions of p -toluenesulfohydrazide with R-isothiocyanates and were used in complexation reactions with Ag I and Au I , leading to the formation of complexes of composition [M(HL R ) 2 ]X (M = Ag or Au; X = NO 3 - or Cl - ). All compounds were characterized by FTIR, 1 H NMR, UV-vis, emission spectroscopy and elemental analysis. Some representatives were additionally studied by ESI-MS and single-crystal XRD. Their properties were further analyzed by DFT calculations. Their cytotoxicity on Vero cells and the extracellular leishmanicidal activity on Leishmania infantum and Leishmania braziliensis cells were evaluated. Additionally, the interaction of the complexes with the Old Yellow enzyme of the L. braziliensis (LbOYE) was examined. The biological tests showed that some compounds present remarkable leishmanicidal activity, even higher than that of the standard drug Glucantime, with different selectivity for the two species of Leishmania . Finally, the interaction studies with LbOYE revealed that this enzyme could be one of their biological targets.
Keyphrases
- induced apoptosis
- cell cycle arrest
- quantum dots
- ms ms
- solid state
- high resolution
- density functional theory
- sensitive detection
- multiple sclerosis
- gold nanoparticles
- magnetic resonance
- mass spectrometry
- molecular dynamics
- visible light
- oxidative stress
- molecular dynamics simulations
- single molecule
- molecular docking
- single cell
- silver nanoparticles
- adverse drug
- genetic diversity
- monte carlo