DNA methylation associated with polycystic ovary syndrome: a systematic review.

Arícia Gomes Miranda Marcelo Marcondes Seneda Luciana Rocha Faustino

Published in: Archives of gynecology and obstetrics (2023)

The most relevant genes related to PCOS were INSR, LHCGR, and RAB5B, which may be epigenetically altered in DNA, with the first two genes hypomethylated and the last hypermethylated. The epigenetic changes presented in the genes related to PCOS or their promoters were only at the CpG sites.

Keyphrases

polycystic ovary syndrome
dna methylation
genome wide
insulin resistance
gene expression
bioinformatics analysis
genome wide identification
adipose tissue
single molecule
metabolic syndrome
circulating tumor
copy number
cell free