Hexokinases II-mediated glycolysis governs susceptibility to crizotinib in ALK-positive non-small cell lung cancer.

Caiyu LinHengyi ChenRui HanLi LiConghua LuShuai HaoYubo WangYong He

Published in: Thoracic cancer (2021)

These results indicate that HK2-mediated glycolysis plays a crucial role in the increased tolerance of ALK+ NSCLC cells to crizotinib. 2DG may sensitize ALK+ NSCLC to crizotinib via suppression of HK2-mediated glycolysis and the AKT/mTOR signaling pathway.

Keyphrases

advanced non small cell lung cancer
epidermal growth factor receptor
signaling pathway
induced apoptosis
small cell lung cancer
cell proliferation
pi k akt
epithelial mesenchymal transition
oxidative stress
cell cycle arrest