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Zoledronic acid relieves steroid-induced avascular necrosis of femoral head via inhibiting FOXD3 mediated ANXA2 transcriptional activation.

Yu LinMin ChenWenbin GuoShengliang QiuLihui ChenWenge Liu
Published in: Bone (2024)
ZOL alleviated SANFH through regulating FOXD3 mediated ANXA2 transcriptional activity and then promoting PI3K/AKT/mTOR pathway, revealing that FOXD3 might be a target for ZOL in SANFH treatment.
Keyphrases
  • gene expression
  • transcription factor
  • signaling pathway
  • high glucose
  • diabetic rats
  • heat shock
  • oxidative stress
  • endothelial cells
  • heat stress