Inhibition of Trypanosoma evansi Protein-Tyrosine Phosphatase by Myristic Acid Analogues Isolated from Khaya senegalensis and Tamarindus indica.

Emeka John DingwokeFatima Amin AdamudeChimee Ethel ChukwuochaAhmed Adamu AmbiNwobodo Ndubuisi NwobodoAbdullahi Balarabe SallauHumphrey Chukwuemeka Nzelibe

Published in: Journal of experimental pharmacology (2019)

Analogues of myristic acid are potent inhibitors of protein-tyrosine phosphatase that could be developed as trypanocide to inhibit the enzymatic activity of protein-tyrosine phosphatase in order to prevent transmission of trypanosomes.

Keyphrases

protein protein
amino acid
molecular docking
binding protein
protein kinase
molecular dynamics simulations
structure activity relationship