Effects of HER Family-targeting Tyrosine Kinase Inhibitors on Antibody-dependent Cell-mediated Cytotoxicity in HER2-expressing Breast Cancer.

Denis M CollinsStephen F MaddenNicola GaynorDalal AlSultanMarion Le GalAlexander J EustaceKathy A GatelyClare HughesAnthony M DaviesThamir MahgoubJo BallotSinead Toomey Aisling E O'Connor William M Gallagher Frankie Ann Holmes Virginia EspinaLance LiottaBryan T HennessyKenneth J O'Byrne Max HasmannBirgit BossenmaierNorma O'DonovanJohn Crown

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

TKIs differentially alter tumor cell phenotype which can impact NK cell-mediated response to coadministered antibody therapies. mAb-induced ADCC response is relevant when rationalizing combinations for clinical investigation.

Keyphrases

single cell
cell therapy
nk cells
high glucose
oxidative stress
drug induced
breast cancer risk