Integrating manual diagnosis into radiomics for reducing the false positive rate of 18F-FDG PET/CT diagnosis in patients with suspected lung cancer.

The established hybrid nomogram integrating PET/CT RS and manual diagnosis can significantly reduce FPR, improve diagnostic accuracy and enhance clinical benefit compared to manual diagnosis. By integrating manual diagnosis, the performance of this hybrid nomogram is superior to PET/CT RS, indicating the importance of clinicians' judgement as an essential information source for improving radiomics diagnostic approaches.