Increased M1 Macrophages Infiltration Correlated With Poor Survival Outcomes and Radiation Response in Gliomas.

Zhaoming ZhouLei WenMingyao LaiChangguo ShanJian WangRong WangHainan LiLonghua ChenLinbo CaiMeijuan ZhouCheng Zhou

Published in: Dose-response : a publication of International Hormesis Society (2020)

Our study demonstrated that M1 macrophages correlated with WHO grades and predicted robustly for the survival performance for GBM patients. Increased infiltration of M1 macrophages was associated with a poor radiation response for IDH-wildtype GBM. Together, it will facilitate more precise stratifications of glioma patients based on molecular and immunological surrogates.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
radiation therapy
radiation induced
high grade