The zinc transporter ZIP12 regulates monocrotaline-induced proliferation and migration of pulmonary arterial smooth muscle cells via the AKT/ERK signaling pathways.

Chaoyi YeGuili LianTingjun WangAi ChenWeixiao ChenJin GongLi LuoHuajun WangLiang-Di Xie

Published in: BMC pulmonary medicine (2022)

ZIP12 is involved in MCT-induced pulmonary vascular remodeling and enhances the proliferation and migration of PASMCs. The mechanism of these effects was partially mediated by enhancing the AKT/ERK signaling pathways.

Keyphrases

signaling pathway
pulmonary hypertension
pi k akt
cell proliferation
epithelial mesenchymal transition
high glucose
induced apoptosis
diabetic rats
drug induced
endothelial cells