Anti-cancer therapy with TNFα and IFNγ: A comprehensive review.
Jing ShenZhan Gang XiaoQijie ZhaoMingxing LiXu WuLin ZhangWei HuChi H ChoPublished in: Cell proliferation (2018)
Tumour necrosis factor alpha (TNFα) and interferon gamma (IFNγ) were originally found to be produced by inflammatory cells and play important roles in the immune system and surveillance of tumour growth. By activating distinct signalling pathways of nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and JAK/STAT, TNFα and IFNγ were reported to effectively trigger cell death and perform powerful anti-cancer effects. In this review, we will discuss the new advancements of TNFα and IFNγ in anti-cancer therapy.
Keyphrases
- nuclear factor
- dendritic cells
- rheumatoid arthritis
- signaling pathway
- immune response
- cell death
- cancer therapy
- induced apoptosis
- toll like receptor
- cell cycle arrest
- oxidative stress
- pi k akt
- public health
- drug delivery
- lps induced
- mesenchymal stem cells
- stem cells
- endoplasmic reticulum stress
- tyrosine kinase
- smoking cessation
- bone marrow
- replacement therapy