Evaluation of response in patients with hepatocellular carcinoma treated with intratumoral dendritic cell vaccination using intravoxel incoherent motion (IVIM) MRI and histogram analysis.

Mats Andersson Oscar Jalnefjord Mikael Montelius Magnus RizellMalin Sternby EilardMaria Ljungberg

Published in: Acta radiologica (Stockholm, Sweden : 1987) (2021)

DW-MRI with IVIM and histogram analysis revealed significant reductions of D* early after treatment as well as an association between D at baseline and smaller tumor growth at three months. The lower percentiles (10th and 50th) were found more important. Further research is needed to confirm our preliminary findings of reduced perfusion after ilixadencel vaccinations, suggesting a treatment effect on HCC.

Keyphrases

contrast enhanced
diffusion weighted imaging
diffusion weighted
magnetic resonance imaging
dendritic cells
computed tomography
magnetic resonance
regulatory t cells
immune response
mass spectrometry
replacement therapy
smoking cessation
high speed