Oleuropein alleviates myocardial ischemia-reperfusion injury by suppressing oxidative stress and excessive autophagy via TLR4/MAPK signaling pathway.

Jia HeLiting HuangKaili SunJilang LiShan HanXiang GaoQin-Qin WangShilin YangWen SunHongwei Gao

Published in: Chinese medicine (2024)

This study shows that OP binds to TLR4 to regulate oxidative stress and autophagy for protecting damaged cardiomyocytes, supporting that OP can be a potential therapeutic agent for MIRI.

Keyphrases

oxidative stress
ischemia reperfusion injury
signaling pathway
induced apoptosis
toll like receptor
inflammatory response
diabetic rats
dna damage
immune response
pi k akt
cell death
endoplasmic reticulum stress
epithelial mesenchymal transition
left ventricular
weight gain
heat shock
mouse model