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Increasing the sensitivity of Simoa via bead count reduction facilitates the quantification of pTau-181 in dried plasma spots.

Pablo MohauptJérôme VialaretChristophe HirtzSylvain Lehmann
Published in: Alzheimer's & dementia (New York, N. Y.) (2024)
Implementing DPS sampling and pTau-181 quantification could increase participation from underrepresented groups in AD research. However, additional assay optimization and an in-depth study of preanalytical sample stability are essential for the transition to clinical applicability.
Keyphrases
  • physical activity
  • high throughput
  • quality improvement
  • peripheral blood