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Population Genetic Analysis of Six Chinese Indigenous Pig Meta-Populations Based on Geographically Isolated Regions.

Lige ZhangSongyuan ZhangFengting ZhanMingkun SongPeng ShangFangxian ZhuJiang LiFeng YangXiu-Ling LiRuimin QiaoXuelei HanXinjian LiGang LiuKejun Wang
Published in: Animals : an open access journal from MDPI (2023)
The diversification of indigenous pig breeds in China has resulted from multiple climate, topographic, and human cultural influences. The numerous indigenous pig breeds can be geographically divided into six meta-populations; however, their genetic relationships, contributions to genetic diversity, and genetic signatures remain unclear. Whole-genome SNP data for 613 indigenous pigs from the six Chinese meta-populations were obtained and analyzed. Population genetic analyses confirmed significant genetic differentiation and a moderate mixture among the Chinese indigenous pig meta-populations. The North China (NC) meta-population had the largest contribution to genetic and allelic diversity. Evidence from selective sweep signatures revealed that genes related to fat deposition and heat stress response ( EPAS1 , NFE2L2 , VPS13A , SPRY1 , PLA2G4A , and UBE3D ) were potentially involved in adaptations to cold and heat. These findings from population genetic analyses provide a better understanding of indigenous pig characteristics in different environments and a theoretical basis for future work on the conservation and breeding of Chinese indigenous pigs.
Keyphrases
  • genetic diversity
  • genome wide
  • copy number
  • dna methylation
  • endothelial cells
  • adipose tissue
  • high intensity
  • single cell
  • electronic health record
  • heat stress
  • current status
  • tertiary care
  • drug induced