Bmpr2 mutant mice are an inadequate model for studying iron deficiency in pulmonary hypertension.
Vida ZhangTomas GanzElizabeta NemethSoban UmarAirie KimPublished in: Pulmonary circulation (2022)
As bone morphogenetic protein receptor type II (Bmpr2) mutations are the most common genetic cause of pulmonary arterial hypertension (PAH), and iron deficiency (ID) is associated with worse clinical outcomes in PAH patients, we proposed to use Bmpr2 ± mice to induce a model of ID in pulmonary vascular disease. Our study shows that these transgenic mice are not a good model for this clinical phenomenon.
Keyphrases
- pulmonary arterial hypertension
- pulmonary hypertension
- iron deficiency
- pulmonary artery
- end stage renal disease
- ejection fraction
- high fat diet induced
- chronic kidney disease
- prognostic factors
- metabolic syndrome
- genome wide
- skeletal muscle
- dna methylation
- polycyclic aromatic hydrocarbons
- insulin resistance
- gene expression
- patient reported