Medial Orbitofrontal Neurons Preferentially Signal Cues Predicting Changes in Reward during Unblocking.

This study uniquely examines encoding in rodent mOFC at the single-unit level in response to cues that predict more, less, or no change in reward in rats during training in a Pavlovian unblocking task, finding more cells responding to change-predictive cues and stronger activity in response to cues predictive of less reward.