Pathological autoantibody internalisation in myositis.
Iago Pinal-FernandezSandra Muñoz-BracerasMaria Casal-DominguezKatherine PakJiram Torres-RuizJon MusaiStefania Dell'OrsoFaiza NazShamima IslamGustavo Gutierrez-CruzMaria Dolores CanoAna Matas-GarciaJoan PadrosaEster Tobias-BarajaGloria GarrabouIban AldecoaGerard EspinosaCarmen Pilar Simeon-AznarAlfredo Guillen-Del-CastilloAlbert Gil-VilaErnesto Trallero-AraguásLisa Christopher-StineThomas E LloydTeerin LiewluckElie NaddafWerner StenzelSteven A GreenbergJosep Maria GrauAlbert Selva-O'CallaghanJose Cesar MilisendaAndrew Lee MammenPublished in: Annals of the rheumatic diseases (2024)
This study demonstrates that, in myositis, autoantibodies are internalised into living cells, causing biological effects consistent with the disrupted function of their autoantigen.