Patients with severe asthenoteratospermia carrying SPAG6 or RSPH3 mutations have a positive pregnancy outcome following intracytoplasmic sperm injection.

Huan WuJiajia WangHuiru ChengYang GaoWangjie LiuZhiguo ZhangHuanhuan JiangWeiyu LiFuxi ZhuMingrong LvChunyu LiuQing TanXiaofeng ZhangChao WangXiaoqing NiYujie ChenBing SongPing ZhouZhaolian WeiFeng ZhangXiaojin HeYunxia Cao

Published in: Journal of assisted reproduction and genetics (2020)

Mutations in ciliopathy-related SPAG6 and RSPH3 cause severe asthenoteratospermia characterized by multiple flagellar malformations, resulting in sterility. ICSI is an optimal management with a positive pregnancy outcome.

Keyphrases

pregnancy outcomes
preterm birth
early onset
drug induced
pregnant women