Dot1l Aggravates Keratitis Induced by Herpes Simplex Virus Type 1 in Mice via p38 MAPK-Mediated Oxidative Stress.

Shanshan WanYiwen ZhouQiong HuangYanning Yang

Published in: Oxidative medicine and cellular longevity (2021)

Our results demonstrated that the inhibition of Dot1l alleviated corneal oxidative stress and inflammation by inhibiting ROS production through the p38 MAPK pathway in HSK. These findings indicated that Dot1l might be a valuable therapeutic target for HSK.

Keyphrases

oxidative stress
herpes simplex virus
dna damage
energy transfer
diabetic rats
ischemia reperfusion injury
induced apoptosis
signaling pathway
cell death
optical coherence tomography
high fat diet induced
type diabetes
wound healing
adipose tissue
skeletal muscle
heat shock
insulin resistance