Quantitative positron emission tomography reveals regional differences in aerobic glycolysis within the human brain.
Tyler BlazeyAbraham Z SnyderYi SuManu S GoyalJohn J LeeAndrei G VlassenkoAna Maria ArbeláezMarcus E RaichlePublished in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2018)
Glucose and oxygen metabolism are tightly coupled in the human brain, with the preponderance of the brain's glucose supply used to generate ATP via oxidative phosphorylation. A fraction of glucose is consumed outside of oxidative phosphorylation despite the presence of sufficient oxygen to do so. We refer to this process as aerobic glycolysis. A recent positron emission tomography study reported that aerobic glycolysis is uniform within gray matter. Here, we analyze the same data and demonstrate robust regional differences in aerobic glycolysis within gray matter, a finding consistent with previously published data.
Keyphrases
- positron emission tomography
- computed tomography
- high intensity
- pet ct
- blood glucose
- pet imaging
- electronic health record
- big data
- protein kinase
- white matter
- type diabetes
- blood pressure
- systematic review
- mass spectrometry
- machine learning
- adipose tissue
- multiple sclerosis
- resting state
- data analysis
- artificial intelligence
- functional connectivity
- metabolic syndrome
- cerebral ischemia
- weight loss