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Targeted Deep Sequencing of Mycosis Fungoides Reveals Intracellular Signaling Pathways Associated with Aggressiveness and Large Cell Transformation.

Marion WobseSabine RothSilke AppenzellerRoland HoubenDavid SchramaMatthias GoebelerEva GeissingerAndreas RosenwaldKatja Maurus
Published in: Cancers (2021)
Our data demonstrate that LCT transition of MF is associated with increased frequency of somatic mutations in cancer-associated genes. In particular, the activation of RAS signaling-together with epigenetic dysregulation-may crucially contribute to the molecular pathogenesis of the LCT phenotype, thus conveying its adverse clinical behavior.
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