Targeted Deep Sequencing of Mycosis Fungoides Reveals Intracellular Signaling Pathways Associated with Aggressiveness and Large Cell Transformation.
Marion WobseSabine RothSilke AppenzellerRoland HoubenDavid SchramaMatthias GoebelerEva GeissingerAndreas RosenwaldKatja MaurusPublished in: Cancers (2021)
Our data demonstrate that LCT transition of MF is associated with increased frequency of somatic mutations in cancer-associated genes. In particular, the activation of RAS signaling-together with epigenetic dysregulation-may crucially contribute to the molecular pathogenesis of the LCT phenotype, thus conveying its adverse clinical behavior.
Keyphrases
- single cell
- signaling pathway
- dna methylation
- genome wide
- electronic health record
- gene expression
- cell therapy
- copy number
- big data
- cancer therapy
- pi k akt
- wild type
- stem cells
- bioinformatics analysis
- single molecule
- bone marrow
- machine learning
- cell proliferation
- oxidative stress
- genome wide analysis
- transcription factor