Obesity-associated methylation in breast tumors: a possible link to disparate outcomes?

Whitney L DoKaren ConneelySheryl Gabram-MendolaUma KrishnamurtiOlivia D'AngeloJasmine Miller-KleinhenzKeerthi GogineniMylin TorresLauren E McCullough

Published in: Breast cancer research and treatment (2020)

We identified novel interactions between obesity-associated methylation and both race and ER status in genes that have been associated with tumor regulation. Our data suggest that dysregulation in two sites may associate with all-cause mortality.

Keyphrases

genome wide
insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
dna methylation
electronic health record
adipose tissue
gene expression
machine learning
body mass index
physical activity
transcription factor
artificial intelligence