Radiolabeling and quality control of therapeutic radiopharmaceuticals: optimization, clinical implementation and comparison of radio-TLC/HPLC analysis, demonstrated by [ 177 Lu]Lu-PSMA.

Eline L HooijmanCarolline M NtihaboseThom G A ReuversJulie NonnekensElse A AalbersbergJordy R J P van de MerbelJudith E HuijmansStijn L W KoolenJeroen J M A HendrikxErik de Blois

Published in: EJNMMI radiopharmacy and chemistry (2022)

Lu]Lu-PSMA has less binding affinity and thus likely will influence treatment efficacy. HPLC analysis is therefore essential to include in at least the validation phase of radiopharmaceutical implementation to ensure clinical treatment quality.

Keyphrases

ms ms
quality control
pet ct
primary care
healthcare
quality improvement
simultaneous determination
pet imaging
high performance liquid chromatography
computed tomography
solid phase extraction
replacement therapy
positron emission tomography