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Skin-infiltrating basophils promote atopic dermatitis-like inflammation via IL-4 production in mice.

Yoshinori YamanishiKotone MogiKazufusa TakahashiKensuke MiyakeSoichiro YoshikawaHajime Karasuyama
Published in: Allergy (2020)
Skin-infiltrating basophils promoted OX-induced AD-like skin inflammation through their local production of IL-4, rather than the induction of Th2 cell differentiation in draining LNs. This study suggests that the selective targeting of basophils could be a beneficial strategy in the treatment of a certain type of AD.
Keyphrases
  • soft tissue
  • oxidative stress
  • atopic dermatitis
  • wound healing
  • diabetic rats
  • high glucose
  • cancer therapy
  • high fat diet induced
  • insulin resistance
  • combination therapy
  • replacement therapy