Impact of cerebral hypoperfusion-reperfusion on optic nerve integrity and visual function in the DBA/2J mouse model of glaucoma.
Stephan Alexander FraenklQuentin SimonYeni YucelNeeru GuptaValéry V WittwerBeatrice E FruehStefan A TschanzPublished in: BMJ open ophthalmology (2022)
Elevated intraocular pressure in the DBA/2J mouse model of glaucoma leads to a much more pronounced optic nerve atrophy compared with transient forebrain hypoperfusion and reperfusion by BCCAO. A supposed worsening effect of an altered perfusion added to the pressure-related damage could not be detected.
Keyphrases
- optic nerve
- cerebral ischemia
- mouse model
- subarachnoid hemorrhage
- cognitive impairment
- brain injury
- optical coherence tomography
- blood brain barrier
- acute myocardial infarction
- acute ischemic stroke
- oxidative stress
- contrast enhanced
- magnetic resonance imaging
- heart failure
- percutaneous coronary intervention
- coronary artery disease
- magnetic resonance
- acute coronary syndrome
- drug induced