Impact of cerebral hypoperfusion-reperfusion on optic nerve integrity and visual function in the DBA/2J mouse model of glaucoma.

Stephan Alexander FraenklQuentin SimonYeni YucelNeeru GuptaValéry V WittwerBeatrice E FruehStefan A Tschanz

Published in: BMJ open ophthalmology (2022)

Elevated intraocular pressure in the DBA/2J mouse model of glaucoma leads to a much more pronounced optic nerve atrophy compared with transient forebrain hypoperfusion and reperfusion by BCCAO. A supposed worsening effect of an altered perfusion added to the pressure-related damage could not be detected.

Keyphrases

optic nerve
cerebral ischemia
mouse model
subarachnoid hemorrhage
cognitive impairment

brain injury
optical coherence tomography
blood brain barrier
acute myocardial infarction
acute ischemic stroke

oxidative stress
contrast enhanced
magnetic resonance imaging
heart failure
percutaneous coronary intervention

coronary artery disease
magnetic resonance
acute coronary syndrome
drug induced