Melatonin enhances osteoblastogenesis of senescent bone marrow stromal cells through NSD2-mediated chromatin remodelling.

Ying XieNa HanFeng LiLijuan WangGerui LiuMeilin HuSheng WangXuelei WeiJing GuoHongmei JiangJingjing WangXin LiYixuan WangJingya WangXiyun BianZhongjiao ZhuHui ZhangChunhua LiuXiaozhi LiuZhiqiang Liu

Published in: Clinical and translational medicine (2022)

Collectively, our study dissects previously unreported mechanistic insights into the epigenetic regulating machinery of melatonin in meliorating osteogenic differentiation of senescent BMSC, and provides evidence for application of melatonin in preventing aging-associated bone loss.

Keyphrases

bone loss
bone marrow
gene expression
dna methylation
mesenchymal stem cells
dna damage
transcription factor
genome wide