Pyrone Derivatives from a Mangrove Endophytic Fungus Phomopsis asparagi LSLYZ-87.
Yayue LiuWencong YangQingnan LiaoZhi-Gang ShePublished in: Chemistry & biodiversity (2022)
Chemical investigation of the endophytic fungus Phomopsis asparagi LSLYZ-87 cultured on PDB medium led to the isolation of two new pyrone derivatives, phomasparapyrone A (1), and phomasparapyrone B (2), together with the known kojic acid (3). Their planar structures were connected through 1D and 2D NMR spectroscopic data. And the stereo structures of 1 and 2 were defined by comparison of the experimental ECD spectra to calculated one. All isolates were evaluated for their anti-neuroinflammatory activities. Among them, compound 2 showed moderate inhibition on NO accumulation induced by LPS on BV-2 cells in a dose dependent manner at 30, 40 and 50 μM, and without cytotoxicity in a concentration of 50.0 μM.
Keyphrases
- high resolution
- induced apoptosis
- cell cycle arrest
- magnetic resonance
- molecular docking
- inflammatory response
- structure activity relationship
- electronic health record
- lps induced
- high intensity
- oxidative stress
- signaling pathway
- density functional theory
- cell death
- anti inflammatory
- solid state
- cell proliferation
- light emitting