Outcomes of relapsed/refractory extracranial germ cell tumors treated on conventional salvage chemotherapy without stem cell rescue: Experience from a tertiary cancer center.
Subramaniam RamanathanPrasad MayaTushar VoraCheriyalinkal Parambil BadiraSeema KembhaviMukta RamadwarNehal KhannaSiddhartha LaskarMary Ann MuckadenSajid S QureshiShripad BanavaliGirish ChinnaswamyPublished in: Pediatric blood & cancer (2023)
Primary refractory GCTs, extragonadal rel-GCTs, and rel/ref-GCTs with a poor biochemical response did poorly with conventional SC and need alternative treatment strategies. The rel/ref-testicular GCTs had the best chance of salvage despite a second recurrence (5-year EFS and OS: 28.60% and 42.90%, respectively).
Keyphrases
- germ cell
- stem cells
- papillary thyroid
- acute lymphoblastic leukemia
- acute myeloid leukemia
- diffuse large b cell lymphoma
- multiple myeloma
- internal carotid artery
- squamous cell
- locally advanced
- squamous cell carcinoma
- skeletal muscle
- metabolic syndrome
- free survival
- radiation therapy
- childhood cancer
- insulin resistance