Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma.
Shinichi HaradaKeiki NagaharuYouichirou BabaTetsuya MurataToshiro MizunoKeiki KawakamiPublished in: Case reports in oncological medicine (2017)
Tumor lysis syndrome (TLS) is an oncological emergency caused by massive cytolysis of malignant cells. This syndrome eventually induces metabolic abnormalities. TLS is observed mainly among tumors with rapid cell proliferation or high sensitivity to antineoplastic treatment. In rare cases, TLS occurs without any cytotoxic treatment. Previous reports have shown that alternative stress including proceeding infection or an operation might play a role in TLS. However, exact mechanism of spontaneous TLS remains unknown. Here, we describe a case of a 59-year-old woman who presented with dedifferentiated endometrial adenocarcinoma and developed TLS without any cytotoxic chemotherapy. Although spontaneous TLS in solid malignancies are extremely rare, clinicians should consider the possibilities of TLS especially in aggressive solid tumors.
Keyphrases
- case report
- cell proliferation
- squamous cell carcinoma
- locally advanced
- emergency department
- public health
- induced apoptosis
- prostate cancer
- radiation therapy
- cell cycle
- density functional theory
- robot assisted
- quantum dots
- heat stress
- adverse drug
- molecular dynamics
- sensitive detection
- replacement therapy
- loop mediated isothermal amplification