Ring expansion and fused cyclization catalysis to construct indoloquinazolinones with functionalization.

In this study, a straightforward, moisture insensitive, and regioselective Fe III -Cu II / p -TSA-Cu I catalyzed reaction is achieved from readily available isatin and 2-alkynylaniline to furnish diverse 12-benzoyl/benzyl/alkyl indolo[1,2- c ]quinazolin-6(5 H )-ones. This catalytic method includes C-C cleavage, multi bond forming ring expansion, fused-ring construction, broad substrate scope, gram-scale producibility, and high atom economy.