Reproductive genetics and health.
Margot Julia WyrwollJohanna SteingröverPublished in: Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V (2024)
For those affected, infertility is linked to impaired overall health and reduced life expectancy. In particular, infertile individuals bear an increased risk for cardiovascular disease (CVD) and different types of cancer, partially due to lifestyle differences and to genetic alterations that cause both infertility and an increased cancer risk. Genetic variants causing an increased CVD risk are more commonly found in infertile individuals, but their link to infertility remains unclear. Offspring of infertile couples, conceived via medically assisted reproduction, are as likely as their parents to exhibit or develop adiposity, hormonal alterations such as insulin resistance, and infertility. The effects on health of subsequent generations are completely unclear.
Keyphrases
- polycystic ovary syndrome
- insulin resistance
- public health
- cardiovascular disease
- healthcare
- high fat diet
- metabolic syndrome
- mental health
- adipose tissue
- skeletal muscle
- type diabetes
- health information
- health promotion
- physical activity
- high fat diet induced
- squamous cell carcinoma
- risk assessment
- genome wide
- dna methylation
- gene expression
- weight gain
- squamous cell
- childhood cancer