Triple blockade of Ido-1, PD-L1 and MEK as a potential therapeutic strategy in NSCLC.
Carminia Maria Della CorteVincenza CiaramellaKavya RamkumarGiovanni VicidominiAlfonso FiorelliValerio NardoneSalvatore CappabiancaImmacolata CozzolinoFederica Zito MarinoGaetano Di GuidaQi WangRobert CardnellCarl Michael GayDavide CiardielloErika MartinelliTeresa TroianiGiulia MartiniStefania NapolitanoJing WangLauren Averett ByersFortunato CiardielloFloriana MorgilloPublished in: Journal of translational medicine (2022)
We show that Ido-1 activation is a possible escape mechanism to immune-mediated cell death induced by combination of PD-L1 and MEK inhibitors: also, we show that triple combination of anti-PD-L1, anti-MEK and anti-Ido-1 drugs may overcome this negative feedback and restore anti-tumor immune response in NSCLC patients' derived three dimensional cultures.