A new mechanism of respiratory syncytial virus entry inhibition by small-molecule to overcome K394R-associated resistance.

Qiaoyun SongHaoyue ZhuManlan QiuJialiao CaiYun HuHaixia YangShuwen RaoYaolan LiManmei LiLijun HuShuqin WangJian HongWen-Cai Ye Heru Chen Ying Wang Wei Tang

Published in: mBio (2024)

infections of both wild-type RSV and the K394R variant by blocking the interaction of viral F protein with its cellular receptor, showing a new mechanism of action for small-molecules to inhibit RSV infection and overcome K394R-associated resistance.

Keyphrases

respiratory syncytial virus
small molecule
wild type
protein protein
binding protein