Fluoropyrimidine usage in cases with hyperammonemia: real-world data study using the Japanese Adverse Drug Event Report (JADER) database.

Mitsuaki Oura Fumiya Oguro Nobukazu AgatsumaHirotaka ImamakiYoshitaka Nishikawa

Published in: Cancer chemotherapy and pharmacology (2023)

Hyperammonemia cases were more likely to be reported with intravenous fluorouracil than orally administered fluoropyrimidines. Fluoropyrimidines might interact with CKD in hyperammonemia cases.

Keyphrases

adverse drug
electronic health record
emergency department
chronic kidney disease
machine learning
drug induced
low dose
data analysis
deep learning