Genetic insights into the association between inflammatory bowel disease and Alzheimer's disease.
Lu ZengCharles C WhiteDavid A BennettHans-Ulrich KleinPhilip Lawrence De JagerPublished in: medRxiv : the preprint server for health sciences (2023)
To our knowledge, this is the first study to systematically contrast the genetic association between IBD and AD, our findings highlight a possible genetically protective effect of IBD on AD even if the majority of effects on myeloid cell gene expression by the two sets of disease variants are distinct. Thus, IBD myeloid studies may not help to accelerate AD functional studies, but our observation reinforces the role of myeloid cells in the accumulation of tau proteinopathy and provides a new avenue for discovering a protective factor.
Keyphrases
- gene expression
- dendritic cells
- bone marrow
- acute myeloid leukemia
- copy number
- ulcerative colitis
- genome wide
- induced apoptosis
- dna methylation
- case control
- healthcare
- magnetic resonance
- cell cycle arrest
- cell therapy
- oxidative stress
- stem cells
- magnetic resonance imaging
- cognitive decline
- computed tomography
- cell death