Impact of HSD17B13 rs72613567 genotype on hepatic decompensation and mortality in patients with portal hypertension.
Bernhard ScheinerAlbert Friedrich StättermayerPhilipp SchwablTheresa A BucsicsRafael PaternostroDavid BauerBenedikt SimbrunnerRalf SchmidtRodrig MarculescuArnulf FerlitschMarkus Peck-RadosavljevicMatthias PinterMichael TraunerThomas ReibergerPeter FerenciMattias MandorferPublished in: Liver international : official journal of the International Association for the Study of the Liver (2019)
In patients with viral hepatitis- and ALD-induced portal hypertension, the T > TA-variant was not protective of hepatic decompensation and mortality. Further studies should investigate the pathophysiological mechanisms underlying the effects of HSD17B13 genotype at different stages of liver disease.