Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo.

Alberto Serrano-PozoManuel A Sánchez-GarcíaAntonio Heras-GarvínRosana March-DíazVictoria NavarroMarisa VizueteJosé López-BarneoJavier VitoricaAlberto Pascual

Published in: PloS one (2017)

Our results argue against a hypoxia-induced shift of AβPP proteolysis from the non-amyloidogenic to the amyloidogenic pathways. We discuss the possible methodological caveats of previous in vivo studies.

Keyphrases

liver failure
drug induced
respiratory failure
aortic dissection
case control
endothelial cells