Cardioprotective actions of nitroxyl donor Angeli's salt are preserved in the diabetic heart and vasculature in the face of nitric oxide resistance.
Anida VelagicJasmin Chendi LiChengxue Helena QinMandy LiMinh DeoSarah A MarshallDovile AndersonOwen L WoodmanJohn D HorowitzBarbara K Kemp-HarperRebecca Helen RitchiePublished in: British journal of pharmacology (2022)
This is the first evidence that inotropic and lusitropic responses are preserved, and NO• resistance in the coronary and mesenteric vasculature is circumvented, by the HNO donor Angeli's salt in T2DM. These findings highlight the cardiovascular therapeutic potential of HNO donors, especially in emergencies such as acute ischaemia or heart failure.
Keyphrases
- heart failure
- nitric oxide
- liver failure
- coronary artery disease
- type diabetes
- coronary artery
- atrial fibrillation
- left ventricular
- respiratory failure
- hydrogen peroxide
- drug induced
- wound healing
- aortic dissection
- intensive care unit
- kidney transplantation
- adipose tissue
- weight loss
- aortic stenosis
- insulin resistance
- extracorporeal membrane oxygenation