TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility.
Louise K FarmerRuth RollasonDaniel J WhitcombLan NiAlexander GoodliffAbigail C LayLutz BirnbaumerKate J HeesomShang-Zhong XuMoin A SaleemGavin I WelshPublished in: Journal of the American Society of Nephrology : JASN (2019)
Our data demonstrate that independent of TRPC6 channel activity, the physical interaction between TRPC6 and calpain in the podocyte is important for cell motility and detachment and demonstrates a scaffolding role of the TRPC6 protein in disease.
Keyphrases
- vascular smooth muscle cells
- cell adhesion
- biofilm formation
- diabetic nephropathy
- physical activity
- mental health
- single cell
- angiotensin ii
- high glucose
- electronic health record
- big data
- cell therapy
- escherichia coli
- stem cells
- machine learning
- mesenchymal stem cells
- small molecule
- endothelial cells
- binding protein
- artificial intelligence
- data analysis