Integrative Genomic Analysis of Pediatric Myeloid-Related Acute Leukemias Identifies Novel Subtypes and Prognostic Indicators.
Maarten FornerodJing MaSanne NoortYu LiuMichael P WalshLei ShiStephanie NanceYanling LiuYuanyuan WangGuangchun SongTamara LamprechtJohn EastonHeather L MulderDonald YergeauJacquelyn MyersJennifer L KamensEsther A ObengMartina PigazziMarie JarosovaCharikleia KelaidiSophia PolychronopoulouJatinder Kaur LambaSharyn D BakerJeffrey E RubnitzDirk ReinhardtMarry M van den Heuvel-EibrinkFranco LocatelliHenrik HasleJeffery M KlcoJames R DowningJinghui ZhangStanley PoundsC Michel ZwaanTanja A GruberPublished in: Blood cancer discovery (2021)
Immunophenotype and somatic mutations play a significant role in treatment approach and risk stratification of acute leukemia. We conducted an integrated genomic analysis of pediatric myeloid malignancies and found that a combination of genetic and transcriptional readouts was superior to immunophenotype and genomic mutations in identifying biological subtypes and predicting outcomes. This article is highlighted in the In This Issue feature, p. 549.