Enhanced medullary and extramedullary granulopoiesis sustain the inflammatory response in lupus nephritis.

Eleni ZervopoulouMaria GrigoriouStavros A DoumasDanae YiannakouPavlos PavlidisGilles GasparoniJörn WalterAnastasia FiliaHarikleia GakiopoulouAggelos BanosIoannis MitroulisDimitrios T Boumpas

Published in: Lupus science & medicine (2024)

These data support a key role of granulocytes derived from primed HSPCs both at medullary and extramedullary sites in the pathogenesis of LN. EMH and TI contribute to SLE by sustaining the systemic inflammatory response and increasing the risk for flare.

Keyphrases

inflammatory response
lipopolysaccharide induced
lps induced
toll like receptor
systemic lupus erythematosus
electronic health record
disease activity
big data
rheumatoid arthritis
immune response