Engineering PD-1-targeted small protein variants for in vitro diagnostics and in vivo PET imaging.

Joanna Maria MierzwickaHana PetrokováLeona Rašková KafkováPetr KosztyuJiří ČernýMilan KuchařMiloš PetříkKateřina BendováKristýna KrasulováYaroslava GrozaLucie VaňkováShiv BharadwajNatalya PanovaMichal KřupkaJozef ŠkardaMilan RaškaPetr Malý

Published in: Journal of translational medicine (2024)

Using directed evolution, we developed a unique set of small binding proteins that can improve PD-1 diagnostics in vitro as well as in vivo using PET/CT imaging.

Keyphrases

pet ct
pet imaging
positron emission tomography
high resolution
computed tomography
copy number
cancer therapy
gene expression
protein protein
binding protein
mass spectrometry
fluorescence imaging