p53 protein accumulation predicts malignant progression in Barrett's metaplasia: a prospective study of 275 patients.

Mamoun YounesKeith BrownGregory Y LauwersGulchin ErgunFrank MerianoA Carl SchmulenAlberto BarrosoAtilla Ertan

Published in: Histopathology (2017)

We conclude that p53 protein accumulation, detected by immunohistochemistry in aggregates of cells, is a significant predictor of malignant progression in patients with BM.

Keyphrases

induced apoptosis
protein protein
amino acid
cell cycle arrest
binding protein
oxidative stress
endoplasmic reticulum stress
cell death
signaling pathway
cell proliferation
pi k akt