Multifunctional nanocarriers of Fe 3 O 4 @PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery.
Phan Quoc ThongThi Thu Huong LeNguyen Dac TuHoang Thi My NhungLam KhanhDo Hung ManhPham Hong NamNguyen Xuan PhucJavier Alonso MasaJu QiaoSrinivas SridharPhuong Thu HaManh-Huong PhanNguyễn Thị Kim ThanhPublished in: Nanomedicine (London, England) (2023)
Background: Despite medicinal advances, cancer is still a big problem requiring better diagnostic and treatment tools. Magnetic nanoparticle (MNP)-based nanosystems for multiple-purpose applications were developed for these unmet needs. Methods: This study fabricated novel trifunctional MNPs of Fe 3 O 4 @PLA-PEG for drug release, MRI and magnetic fluid hyperthermia. Result: The MNPs provided a significant loading of curcumin (∼11%) with controllable release ability, a high specific absorption rate of 82.2 W/g and significantly increased transverse relaxivity ( r 2 = 364.75 mM -1 s -1 ). The in vivo study confirmed that the MNPs enhanced MRI contrast in tumor observation and low-field magnetic fluid hyperthermia could effectively reduce the tumor size in mice bearing sarcoma 180. Conclusion: The nanocarrier has potential for drug release, cancer treatment monitoring and therapy.
Keyphrases
- drug delivery
- drug release
- cancer therapy
- contrast enhanced
- magnetic resonance imaging
- molecularly imprinted
- diffusion weighted imaging
- computed tomography
- squamous cell carcinoma
- mesenchymal stem cells
- adipose tissue
- mass spectrometry
- insulin resistance
- skeletal muscle
- squamous cell
- metal organic framework
- bone marrow
- cell therapy