STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia.

Marjolaine DebantMiguel BurgosPatrice HemonPaul BuscagliaTinhinane FaliSarra MelayahNelig Le GouxChristophe VandierMarie Potier-CartereauJacques-Olivier PersAdrian TempesculChristian BerthouCristina BagaceanOlivier MignenYves Renaudineau

Published in: Journal for immunotherapy of cancer (2019)

These data establish the critical role of a newly discovered BCR independent Ca2+ entry in CLL evolution, provide new insights into CLL pathophysiology, and support innovative therapeutic perspectives such as targeting STIM1 located at the plasma membrane.

Keyphrases

chronic lymphocytic leukemia
acute lymphoblastic leukemia
multiple sclerosis
electronic health record
tyrosine kinase
cancer therapy
big data
chronic myeloid leukemia
machine learning
protein kinase
drug delivery
data analysis
artificial intelligence
deep learning