Association of epicardial fat thickness assessed by echocardiography with the severity of coronary artery disease.
Alireza RostamzadehKamal KhademvataniMir Hossein Seyed MohammadzadehShahrzad AshoriMojgan Hajahmadi PoorrafsanjaniBehzad RahimiBehshid GhadrdoostPublished in: Journal of cardiovascular and thoracic research (2020)
Introduction: Epicardial fat thickness (EFT) can reflect risk of cardiovascular disease particularly coronary artery disease (CAD). The aim of this study was to investigate the association of EFT assessed by echocardiography and presence as well as severity of CAD. Methods: Two hundred and twenty consecutive patients who candidate for coronary angiography because of possible CAD were studied. EFT was evaluated in standard parasternal long axis (PlAX) and parasternal short axis (PSAX) view from 3 cardiac cycles at the end of systole and diastole. The severity of CAD was defined in two ways: (1) SYNTAX score, (2) number of vessels with significant lesion. Results: PLAX (EFTS) (EFT in systole) and PLAX (EFTd) (EFT in diastole) were significantly higher in patients with CAD in comparison with patients without CAD (P = 0.046, P = 0.041 respectively). There was a significant correlation between PLAX (EFTS) (P = 0.05), PLAX (EFTd) (P = 0.04) and SYNTAX score. There was no statistically significant relationship between EFT and number of diseased vessel (P > 0.05). Multivariate analysis was done for adjusting the effects of confounding factors and it showed that EFT (OR: 10.53, P = 0.004) was significantly correlated severe CAD as assessed by the SYNTAX score. Conclusion: EFT assessed by transthoracic echocardiography was higher significantly in patients with CAD than in normal patients. EFT as an easily available and cost-effective echocardiographic feature might be useful to predict complexity of CAD.
Keyphrases
- coronary artery disease
- cardiovascular events
- percutaneous coronary intervention
- coronary artery bypass grafting
- left ventricular
- end stage renal disease
- ejection fraction
- cardiovascular disease
- pulmonary hypertension
- newly diagnosed
- chronic kidney disease
- computed tomography
- peritoneal dialysis
- aortic stenosis
- adipose tissue
- prognostic factors
- optical coherence tomography
- machine learning
- early onset
- mitral valve
- atrial fibrillation
- acute coronary syndrome
- patient reported outcomes
- transcatheter aortic valve replacement
- drug induced
- clinical evaluation