Perinatal diet influences health and survival in a mouse model of leukemia.
Dushani L PalliyaguruAnnamaria L RudderowAlex M SossongKaitlyn N LewisCaitlin YountsKevin J PearsonMichel BernierRafael de CaboPublished in: GeroScience (2020)
The goal of the current study was to determine the role of maternal diet in the perinatal period on the health and survival of the offspring. AKR/J mice, a model described to be susceptible to leukemia development, was used where females were maintained on either standard diet (SD), high sucrose diet, Western diet, or calorie restriction (CR) as they were mated with SD-fed males. Body weights, pregnancy rates, litter size, and litter survival were used as markers of successful pregnancy and pup health. Data indicated that maternal diet had significant effects on litter size, early pup survival, and early pup body weights. As pups matured, the makeup of their respective maternal diet was a predictor of adult metabolic health and survival. Overall, these results suggest that perinatal maternal diet is an important determinant of the health and survival of the offspring and that these effects continue well into adulthood, strongly correlating with lifespan.
Keyphrases
- weight loss
- physical activity
- public health
- healthcare
- mental health
- pregnancy outcomes
- free survival
- health information
- pregnant women
- mouse model
- birth weight
- bone marrow
- high fat diet
- type diabetes
- acute myeloid leukemia
- south africa
- preterm birth
- human health
- adipose tissue
- risk assessment
- big data
- deep learning
- climate change
- social media
- high fat diet induced