Circulating α4β7+ Memory T Cells in Pediatric IBD Patients Express a Polyclonal T Cell Receptor Repertoire.

Adir GamlielLael WernerMarina PinskerNaomi SalamonBatia WeissDror S Shouval

Published in: Clinical and experimental gastroenterology (2020)

α4β7+ memory T cells exhibited a polyclonal repertoire in both control subjects and patients with active inflammatory bowel disease, with high rates of overlap with α4β7- memory T cells. Our study, along with additional recent reports, may suggest that the suppression of intestinal inflammation by vedolizumab is independent of the drug's effect on T cell migration to the gut.

Keyphrases

cell migration
working memory
end stage renal disease
newly diagnosed
ulcerative colitis
ejection fraction
chronic kidney disease
prognostic factors
patient reported outcomes
young adults
drug induced
patient reported
childhood cancer