The effects of ARID1A mutations on colorectal cancer and associations with PD-L1 expression by stromal cells.

Tomohiro KamoriEiji Oki Yoshifumi ShimadaQingjiang HuYuichi HisamatsuKoji AndoMototsugu ShimokawaToshifumi WakaiYoshinao OdaMasaki Mori

Published in: Cancer reports (Hoboken, N.J.) (2021)

We found a higher mutational burden in ARID1A-mutant CRCs, and IHC study showed that ARID1A loss was correlated with high PD-L1 expression in stromal cells regardless of MSI status. These data support the idea that mutant ARID1A is a potential biomarker for CRCs.

Keyphrases

wild type
risk factors
big data
deep learning